肠道微生物与炎性相关疾病的免疫学研究新进展

Recent Advances in Immunological Studies of Intestinal Microbes and Inflammatory Related Diseases

人体自身免疫系统与肠道菌群存在着互相影响的关系。近年大量研究表明,代谢性疾病如糖尿病、痛风、慢性肝炎等的出现与肠道菌群的变化密切相关。健康人群和代谢性疾病患者的肠道微生物有不同程度的差异,可通过药物和饮食的作用,重新调节肠道微生物的分布与构成,有利于疾病的缓解。通过对肠道菌群变化的检测可对代谢性疾病的诊断和治疗有一定的促进作用。本文从免疫学的角度切入,对肠道菌群在糖尿病、炎性肠病和痛风等代谢性疾病发病中的作用机制及肠道菌群在疾病诊断和治疗策略进行了综述。

The relationship between the body’s own immune system and intestinal flora is not only coexist-ing, but also affecting each other. Recent studies have shown that metabolic diseases such as di-abetes, gout, hyperuricemia and other metabolic diseases are closely related to changes in intes-tinal flora. The detection of intestinal flora change may be helpful to the diagnosis and treatment of metabolic diseases. The intestinal microflora of the healthy population and patients with metabolic diseases are different, we can use the drugs and the role of diet, and readjust the distribution of intestinal microflora, which is conducive to disease remission and composition. This article reviewed the pathogenesis of diabetes, hyperuricemia, inflammatory bowel disease and gout, the mechanism of intestinal flora and the development of diagnosis and treatment strategy of the disease.