5-羟色胺系统和多巴胺系统对母性行为的调控

Serotonin and Dopamine Modulate Maternal Behavior

母性行为是一种由母性动机驱动,并且需要一系列动作组织的社会行为。母性行为需要母亲在执行功能、情感和动机方面对后代的反应。近年来发现多巴胺系统和5-羟色胺系统都能调节母性行为,首先,多巴胺D2受体的正常表达对母性行为和母性动机都很重要;其次,5-羟色胺2A受体和2C受体的激动都会破坏母性行为,它们还能够交互调节母性行为。最后,5-羟色胺2A受体可以和多巴胺D2受体交互调节母性行为,5-羟色胺2C受体也能和多巴胺系统交互调节母性行为。本综述可以对母性行为的多巴胺系统和5-羟色胺受体的调控机制提供思路,其中涉及的多巴胺D2受体和5-羟色胺2A受体是抗精神病药的重要靶点,也能为抗精神病对母性行为的影响提供启示。

Maternal behavior is a kind of social behavior driven by maternal motivation and needs a series of actions to organize. Maternal behavior requires maternal responses to off springs in terms of ex-ecutive function, emotion, and maternal motivation. In recent years, it has been found that both the dopamine system and the 5-HT system can regulate maternal behavior. Firstly, the normal ex-pression of dopamine D2 receptors is important for maternal behavior and maternal motivation. Secondly, the activation of both 5-HT 2A and 2C receptors can disrupt maternal behavior, and they interactively regulate maternal behavior. Finally, 5-HT 2A receptors interact with dopamine D2 receptors to regulate maternal behavior, and 5-HT 2C receptors interact with the dopamine system to regulate maternal behavior. This review can provide insights into the regulation mechanism of dopamine system and 5-HT system in maternal behavior. Besides, the dopamine D2 receptors and 5-HT 2A receptors are important targets for antipsychotics, so the review can also provide insights into the effects of antipsychotics on maternal behavior.