抑郁症神经生理机制研究进展

Progress in Neurophysiological Mechanisms of Depression

抑郁症是一种常见的精神障碍疾病,是以显著而持久的情绪低落为主要特征的精神障碍。其主要表现是以情感低落、思维迟缓和精神运动性抑制三大症状为基本特征。部分抑郁症患者伴有严重的焦虑症状,出现自杀观念及行为,给全球带来沉重的疾病负担。抑郁症的病因十分复杂,迄今仍未完全阐明。近年来,国内外对抑郁症的研究从未停止,在抑郁症发病机制的研究上取得了重要进展。文本文通过对以往基因遗传学研究,脑结构和功能研究,神经炎症以及神经内分泌的研究进行阐述,以拓展对抑郁症的认识。

Depression is a common mental disorder that is characterized by significant and persistent de-pressed mood. It is characterized by low emotion, slow thinking and psychomotor inhibition. Some patients with depression have serious anxiety symptoms, suicidal ideas and behaviors, which bring heavy disease burden to the world. The etiology of depression is very complex and has not yet been fully elucidated. In recent years, the research on depression has never stopped at home and abroad, and important progress has been made in the pathogenesis of depression. In this paper, the past genetic studies, brain structure and function studies, neuroinflammation and neuroendocrine studies are briefly described in order to expand the understanding of depression.