生物能量在蛋白质分子中传递的特性和理论研究

The Investigation of Properties and Theory of Bio-energy Transport in Protein Molecules

生物能量在生物体当中的传递是生命科学当中的一个基本问题,它相关于ATP水解放出的能量沿着蛋白质分子的传递,它与蛋白质的动力学特性相关。根据ATP分子水解反应的特性以及蛋白质结构的特点,在Davydov理论的基础上提出了一个新的生物能量传递的理论。在这个理论当中,Amide的振动的集体激发状态用一个两量子准相干态表示,系统的哈密顿量不但包含了Amide振动引起的相邻氨基酸残基的位移,而且包含了相邻Amide之间的共振相互作用所引起的氨基酸残基的相对位置的改变。由这个理论得出的传递生物能量的孤子在生理温度300 K时是热稳定的,它的寿命可达10–10秒,在这个时间之内孤子能传递过上千个氨基酸残基,因此它能在生物过程中起着重要的作用。于是,它是生物体中生物能量传递的一个可利用和正确的理论。

Abstract: Bio-energy transport in the living systems is a basic problem for the life science. It is related to transport of the energy released in APT hydrolysis along the protein molecules, and is determined by dynamic properties of the protein molecules. According to the distribution of ATP molecules and its features of hydro-lysis and structure properties of protein molecules we proposed a new theory of bio-energy transport in pro-tein molecules based on the difficulties and problems of original Davydov model. In this new model we represented the collective excitation of vibrational quanta of amide-I by a two-quantum quasi-coherent wave function, at the same time, both displacement of amino acid residues arising from the vibration of amide-Is and relative displacement of neighboring amino acids caused by resonant interaction between neighboring amides were included in the new Hamiltonian. We obtained that the new soliton transported the bio-energy obtained from the new theory is completely different from Davydov soliton, and thermally stable at biological temperature 300 K, in this case its lifetime is about 10–10 second, in which the new soliton can transport over more than one thousand of amino acid residues in protein molecules. This shows that the soliton is possibly a carrier of the bio-energy transport, and can play an important role in biological processes. Therefore, the new theory is available and valuable to bio-energy transport in living science.