一氧化氮与阿兹海默氏症的治疗

Roles of Nitric Oxide in Treatment of Alzheimer’s Disease

阿尔茨海默症(Alzheimer’s Disease, AD)是一种原发性神经退行性病变,常伴有认知障碍和神经功能障碍。一氧化氮(nitric oxide, NO)是一种重要的传递神经信息的信号分子,对Aβ的生成有重要影响,同时,通过降低神经炎症和氧化氮化及NF-κB通路抑制诱导性一氧化氮合成酶(inducible nitric oxide synthetase, iNOS),从而治疗AD。本文就NO影响AD的发病和治疗的相关性最新研究进行综述。

Alzheimer’s disease (AD) is a primary neurodegenerative disorder with cognitive impairment and autonomic nervous system dysfunction. Nitric oxide (NO) is a major signaling molecule in neurons which influences the formation of Aβ. In addition, NO reduces neurogenic inflammation, oxidation and nitridation and NF-κB passway to restrain inducible nitric oxide synthetase (iNOS). This paper reviewed NO effects on the development and therapy of AD.