生命早期社交孤立破坏社会功能及内侧前额叶皮层调控机制

Early Life Social Isolation Affecting Social Function: Regulation Mechanism of Medial Prefrontal Cortex

该综述文章探讨了生命早期社交孤立对个体心理健康和社会功能的长期负面影响,特别聚焦于内侧前额叶皮层(mPFC)的作用。研究指出,早期的社交孤立可以造成认知障碍和社交技能损害,这些问题可能持续到成年期。结合人类和啮齿动物研究,文章提出社交孤立可能通过损害mPFC神经元发育来影响成年后的社交行为,并提出了可能的改善方案。文章为理解生命早期社交孤立如何通过影响mPFC神经发育进而损害成年后心理健康和社会功能提供了深刻洞察,为制定针对性的心理健康干预措施奠定了理论基础。

This review explores the protracted adverse effects of social isolation in the early stages of life on the psychological well-being and sociability of individuals, with a particular focus on the role of the medial prefrontal cortex (mPFC). The studies suggest that social isolation experienced early in life may lead to cognitive impairments and diminished social capabilities, complications that can persist into adulthood. Synthesizing research from both human subjects and rodent models, the article posits that social isolation may exert its influence on adult social conduct by detrimentally affecting the development of neurons in the mPFC, and proposes potential avenues for amelioration. The paper offers profound insights into understanding how early life social isolation can impact neurodevelopment in the mPFC, thereby impairing mental health and social functionality in later life, thereby laying a theoretical foundation for the formulation of targeted psychological health interventions.