高通量DNA合成测序化学研究进展

Advance in Sequence Chemistry of High-Throughput DNA Sequencing by Synthesis

高通量DNA测序是近年来发展起来的革命性技术,大大推动了快速、廉价获取基因组信息的能力,进而对生命科学产生深刻的影响。测序化学是高通量DNA测序的重要内容,且发展十分迅速;一些构思巧妙的新颖测序化学方法被相继报道,本文综述了高通量DNA测序化学的最新研究进展。

High-throughput DNA sequencing, a revolutionized technology, greatly accelerated mining data from ge- nomes rapidly and cost-efficiently, thus have a profound impact on life sciences. Sequencing chemistry is a pivotal part of high-throughput DNA sequencing, and has been developed dramatically in recently years;a number of ingenious methods of novel sequencing chemistry by synthesis have been reported. In this paper, the development of high- throughput DNA sequencing chemistry by synthesis is reviewed.