解偶联蛋白-1(UCP1)的研究进展及其应用前景

The Research Progress and Application Prospect of Uncoupling Protein 1 (UCP1)

UCP1是唯一在褐色脂肪组织(BAT)中表达的解偶联蛋白质。有别于解偶联蛋白家族其他成员的功能,UCP1的主要功能是参与BAT的产热调节和能量代谢来维持机体的能量代谢平衡。陆续有研究阐明调控UCP1参与BAT产热调节和能量代谢的分子机制,逐渐揭示了UCP1在BAT能量代谢过程中涉及的信号通路与转录调控。这不仅让我们更好地理解UCP1在BAT能量代谢调控中的重要作用,而且为基于褐色脂肪组织的肥胖治疗提供了理论依据。本文阐述了近年来研究发现的UCP1在BAT能量代谢过程中发挥重要作用的信号通路与转录调控,并讨论了多种基于针对褐色脂肪组织的肥胖治疗手段的有效性与可行性。

UCP1 is the only one expression of uncoupling protein in the brown adipose tissue (BAT). Different from the uncoupling protein family other member functions, UCP1’s main function is to participate thermogenic regulation and energy metabolism in BAT to maintain the body’s energy metabolic balance. In succession studies clarify regulation UCP1 participate heat production regulation and energy metabolism molecular mechanism in BAT, gradually reveals the UCP1 inBAT energy metabolic process involved in the signal path and transcription regulation. This not only let us better understand UCP1 inBAT energy metabolism control of the important role, but based on brown adipose tissue obesity treatment provides a theoretical basis. This paper describes the research in recent years UCP1 found in BAT energy metabolism process play an important role in the signal path and transcription regulation, and discussed based on various for brown adipose tissue obesity treatment of the effectiveness and feasibility.