治疗绿脓感染的新策略

New Therapeutic Strategies to Counter PA

受群体效应系统调控。数种新的治疗策略如以生物膜的形成和群体效应系统为靶标正在研发当中,还有噬菌体以及免疫治疗随之孕育而生。随着下一代测序技术和比较基因组学的发展,将给我们设计更为安全有效的药物指引新的思路,使得我们治疗绿脓感染的选择方案发生革命性的变化。

Pseudomonas aeruginosa (PA) is a kind of highly infectious opportunisticpathogen with innate multi-drug resistanceand has ability to acquire drug resistance mechanisms furthermore. In chronicinfections, PA forms biofilms to reduce the effectiveness of antibiotics, whilesecreting a range of virulence factors, many of which are regulated by thepopulation effect system. Several new therapeutic targets such as biological membraneformation and group response systems are being developed, as well as phages andimmunotherapy. With the development of next-generation sequencing technologyand comparative genomics, we will be able to design new ideas for safer andmore effective drugs, which will revolutionize our choice of treatment for PAinfection.