低氧与HIF-1对谷氨酰胺代谢的影响

Effects of Hypoxia and HIF-1 on Glutamine Metabolism

在氧气充足的情况下,葡萄糖可以通过糖酵解和线粒体柠檬酸(TCA)循环为细胞提供能源和碳源。低氧会使TCA循环和电子传递链(ECT)受到抑制,葡萄糖无法被完全氧化,细胞缺乏能源和碳源。为了补充碳源和能源,低氧细胞促进谷氨酰胺代谢途径合成的柠檬酸参与TCA循环,为细胞提供必要的能源和碳源,低氧诱导因子(HIF-1)参与了这一调控。本文主要介绍了低氧环境下的谷氨酰胺代谢,分析了HIF-1与谷氨酰胺代谢之间的相互作用,为低氧糖代谢的调控机制提供理论依据。

When oxygen is sufficient, glucosecan provide energy and carbon source for cells through glycolysis andmitochondrial citric acid (TCA) cycle. Hypoxia can inhibit TCA cycle andelectron transport chain (ECT), glucose cannot be completely oxidized, andcells lack energy and carbon sources. In order to supplement carbon source andenergy, hypoxic cells promote glutamine metabolism, synthesize citric acid,participate in TCA cycle, and provide necessary energy and carbon source forcells. Hypoxia inducible factor-1 (HIF-1) is involved in this regulation. Thispaper mainly introduces glutamine metabolism in hypoxic environment, analyzesthe interaction between HIF-1 and glutamine metabolism, and providestheoretical basis for the regulation mechanism of hypoxic glucose metabolism.