RIPK2:治疗炎症性疾病的新靶点

RIPK2: A New Therapeutic Target for Inflammatory Diseases

炎症是机体受到刺激后出现的一种保护性反应,然而,失调的炎症反应又会引发各种炎症性疾病。受体相互作用蛋白激酶2 (receptor interacting protein kinase 2, RIPK2)是核苷酸结合寡聚化结构域蛋白1和2 (nucleotide-binding oligomerization domain containing protein 1/2, NOD1/2)下游的信号转导分子,在NOD介导的炎症反应中起到了关键的调控作用。NOD-RIPK2信号通路与多种炎症性疾病存在联系,本文对RIPK2的结构功能、RIPK2与炎症性疾病的关系以及RIPK2抑制剂的研发进展进行综述,希望为炎症性疾病的治疗提供新的思路。

Inflammation is a protective response that occurs in response to stimuli. However, dysregulated inflammation can lead to various inflammato-ry diseases. Receptor-interacting protein kinase 2 (RIPK2) is a downstream signaling molecule of nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2) and plays a cru-cial role in regulating NOD-mediated inflammatory responses. The NOD-RIPK2 pathway is associ-ated with various inflammatory diseases. In this review, we summarize the recent advances in un-derstanding the role of RIPK2 in inflammatory diseases and the development of RIPK2 inhibitors, with the aim of providing new ideas for the treatment of inflammatory diseases.