ω-3多不饱和脂肪酸改善2型糖尿病研究进展

Research Progress of ω-3 Polyunsaturated Fatty Acids in Improving Type 2 Diabetes

2型糖尿病(type 2 diabetes mellitus, T2DM)是遗传与环境共同作用的结果,目前公认的2型糖尿病的病理生理变化主要涉及到胰岛素抵抗和胰岛β细胞功能受损。许多研究显示,在T2DM发生发展过程中,炎症与氧化应激是调控胰岛素分泌的重要发病因素。ω-3多不饱和脂肪酸(ω-3 polyunsaturated fatty acid, ω-3PUFAs)在调节炎症反应、糖脂代谢、氧化与抗氧化反应等方面具有重要作用。但能否有效改善T2DM的发病风险,目前尚存争议。本文结合近年来国内外的相关研究进展,综述了ω-3PUFAs在T2DM发病风险的具体作用机制。探讨饮食营养对改善T2DM的意义,为ω-3PUFAs改善T2DM以及相关营养干预提供依据。

Type 2 diabetes (T2DM) is the result of the interaction of heredity and environment. At present, the pathophysiological changes of type 2 diabetes are mainly related to insulin resistance and pancreatic β Impaired cellular function. Many studies have shown that inflammation and oxidative stress are important pathogenic factors regulating insulin secretion during the occurrence and development of T2DM. ω-3 polyunsaturated fatty acids (ω-3 PUFAs) play important roles in regulating inflammatory responses, glucose and lipid metabolism, oxidation, and antioxidant responses. However, there is still controversy over whether it can effectively im-prove the risk of developing T2DM. This article reviews the relevant research progress both domestically and internationally in recent years ω-The specific mechanism of action of ω-3 PUFAs in the risk of developing T2DM. Exploring the significance of dietary nutrition in improving T2DM, in order to ω-3 PUFAs provide a basis for improving T2DM and related nutritional interventions.