评估13种复合型益生菌在调节过敏中的有效性

Evaluation of the Effectiveness of 13 Complex Probiotics in Regulating Allergies

本研究评估13种复合型益生菌在调节过敏方面的有效性。实验设计使用卵清蛋白(OVA)作为过敏原,通过腹腔注射和呼吸喷雾使BALB/c小鼠(n = 6)致敏,并评估三种不同剂量的复合益生菌对过敏的改善情况。结果表明,复合益生菌补充剂以剂量依赖性方式显著降低了气道阻力。此外,与OVA诱导组相比,复合益生菌组的肺冲洗液中的炎症细胞因子IL-4、IL-5和PGE2也呈剂量依赖性降低。脾脏分析表明,复合益生菌可以促进OVA特异性细胞因子和IL-2的分泌,减少非特异性总免疫球蛋白E (IgE),减少OVA特异性IgE的产生。综上所述,13种复合益生菌表现出改善过敏反应的作用。

This study evaluated the effectiveness of 13 complex probiotics in regulating allergies. The experimental design uses ovalbumin (OVA) as the allergen to sensitize BALB/c mice (n = 6) by intraperito- neal injection and respiratory spray, and evaluate the improvement of allergies with three different doses of complex probiotics. The results showed that the airway resistance was significantly reduced by complex probiotics supplementation in a dose-dependent manner. In addition, the inflammatory cytokines IL-4, IL-5, and PGE2 from the lung flushing fluid were also dose-dependently decreased in the complex probiotics groups when compared to the OVA-induced group. Spleen analysis showed that the complex probiotics could promote the secretion of OVA-specific cytokines and IL-2, reduce non-specific total immunoglobulin E (IgE), and reduce OVA-specific IgE production. In summary, 13 kinds of complex probiotics showed the effect of improving allergic reactions.