Hippo信号通路与人类免疫调控的研究进展

Research Progress of Hippo Signaling Pathway and Human Immune Regulation

Hippo信号是与器官大小调控、组织再生和肿瘤发展密切相关的信号通路。最近,越来越多的研究表明Hippo信号通路还在人类免疫调控中发挥重要作用。在本文中,我们主要总结了Hippo信号通路的组成及其调控机制,以及Hippo信号网络中的各种组分在人类免疫系统中的作用,重点介绍了Hippo通路在先天免疫以及抗肿瘤免疫方面的重要调节功能。本文为Hippo通路相关领域研究,以及免疫相关致病机制和治疗策略提供了新的思路。

The hippo signaling pathway is closely related to organ size regulation, tissue regeneration and tumor development. Recently, more and more studies have shown that Hippo signaling pathway also plays an important role in human immune regulation. In this paper, we mainly summarize the composition and regulatory mechanism of Hippo signaling pathway, and the roles of various components of Hippo signaling network in human immune system, focusing on the important regulatory functions of Hippo pathway in innate immunity and anti-tumor immunity. This paper provides a new idea for the study of Hippo pathway and immune-related pathogenesis and treatment strategies.