用于生物医学的碳量子点的表面改性研究进展

Research Progress on Surface Modification of Carbon Quantum Dots for Biomedicine

由于具有良好的发光性能、较低的毒性、灵活的可修饰性等特点,碳量子点(CDs或CQDs)在生物诊疗方面具有巨大的潜力。碳量子点的发光性能及生物功能直接与其表面基团及杂化物的类型相关。研究者们发展了多种物理、化学、杂化等方法对碳量子点的表面进行精准修饰,以期达到更好的选择性、更高的靶向性、更全的功能性及更佳的诊疗效果。本文对近些年来碳量子点表面常用修饰方法进行了综述,并介绍了其在生物传感及疾病诊疗中的应用。

Due to their good luminescence properties, low toxicity, and flexible modifiability, carbon quantum dots (CDs or CQDs) have great potential in biotherapeutics. The luminescence properties and biological functions of CQDs are directly related to the types of surface groups and hybrids. Researchers have developed a variety of physical, chemical, hybrid and other methods to precisely modify the surface of carbon quantum dots, in order to achieve better selectivity, higher targeting, more complete functionality and better diagnosis and treatment effect. In this paper, the commonly used surface modification methods of CQDs in recent years are reviewed, and their applications in biosensing and disease diagnosis and treatment are introduced.