Hippo/YAP途径在肿瘤细胞信号通路交互调控中的作用

The Role of Hippo/YAP Pathway in the Crosstalk of Tumor Cell Signaling Pathways

Hippo/YAP信号通路在维持组织动态平衡和器官再生中发挥重要作用。近几年,越来越多研究表明Hippo/YAP途径与其他肿瘤相关细胞信号通路交互调控,从而影响多种肿瘤的发生和发展过程。本文主要综述了Hippo/YAP信号通路的组成、调控机制,以及Hippo通路关键因子YAP在与其他肿瘤相关细胞信号通路交互调控中的功能及其分子机制。本文将为深入挖掘并揭示Hippo/YAP通路在肿瘤发生中的作用,并以此为开发靶向药物提供思路。

Hippo/YAP signaling pathway plays a decisive role in maintaining tissue homeostasis and organ regeneration. In recent years, more and more studies have shown that Hippo/YAP pathway crosstalk with other tumor-related cell signaling pathways, thus affecting the occurrence and development of various tumors. This paper mainly reviews the composition and regulatory mechanism of Hippo/YAP signaling pathway, as well as the function and molecular mechanism of YAP, a key factor of Hippo pathway, in crosstalk with other tumor-related cell signaling pathways. This paper will provide ideas for further exploring and revealing the role of Hippo/YAP pathway in tumorigenesis and thereby developing targeted drugs.