应激颗粒及其与逆转录病毒的相互作用

Interaction between Stress Granules and Retroviruses

逆转录病毒感染严重威胁人类健康,它与疾病发生息息相关,可引起恶性肿瘤和免疫缺陷症。近年来,越来越多的研究表明,逆转录病毒能够通过与应激颗粒(Stress granules, SGs)的相互作用,在病毒感染以及疾病发生过程中发挥重要功能。本文主要总结了应激颗粒的形成和组分,以及逆转录病毒与应激颗粒的相互作用在病毒感染过程中的作用,为研究逆转录病毒感染以及相关疾病的发生提供新的思路。

Retrovirus infection is a serious threat to human health. It is closely related to the occurrence of diseases and can cause malignant tumors and immunodeficiency. In recent years, more and more studies have shown that retroviruses can play an important role in viral infection and disease occurrence by interacting with stress granules (SGs). This paper mainly summarizes the formation and composition of stress particles, and the role of the interaction between retrovirus and stress particles in the process of virus infection. It provides new ideas for the study of retroviral infection and the occurrence of related diseases.