白细胞介素-8在炎症反应中的作用及其表达调控机制

Role and Expression Regulation of Interleukin-8 in Inflammatory Reaction

白细胞介素-8是诱导炎症反应发生的主要趋化因子。其前体含99个氨基酸残基,经裂解活化后则由细胞分泌释放。白细胞介素-8可与免疫细胞和肿瘤细胞的细胞膜上受体结合,主要经由偶联G蛋白来激活下游相关的信号通路,如丝裂原活化蛋白激酶、磷脂酰肌醇-3-激酶、蛋白激酶C等。本综述将重点阐述这些信号通路的活化机制及其生理和免疫功能。此外,也将概括说明诱导白细胞介素-8表达的转录因子和促进其分泌的机制,并详述主要转录因子,核因子-κB的作用机理。了解白细胞介素-8的功能和调控机制,有助于阐明炎症反应发生的过程和开发新的抗炎药物。

Interleukin-8 (IL-8) is a major chemotaxin that elicits the inflammation response. The proprotein of IL-8 including 99 amino acid residues is activated by proteolysis and then secreted by the cell. IL-8 binds to the receptor on the cell membrane of immune or tumor cells and via G protein-coupled mechanisms stimulates downstream signaling pathways, such as mitogen-activated protein kinase, inositol phosphate-3 kinase and protein kinase C, etc. This review mainly focuses on the activation mechanism of these signaling pathways and related physiological function and immune system. In addition, the review covers the transcription factors that stimulate IL-8 expression and secretion with a great attention on the major factor, nuclear factor-κB. Understanding the function and regulation of IL-8 may elucidate the development of inflammation and discover new anti-inflammatory drugs.