鸢尾素与骨代谢相关性

Correlation between Irisin and Bone Metabolism

鸢尾素是一种由骨骼肌分泌的肌细胞因子,在骨代谢中起主要作用。大量的试验数据表明,鸢尾素可促进骨生成,保护骨细胞免受地塞米松诱导的细胞凋亡,防止骨和肌肉质量损失,并加速骨折愈合。在绝经后女性和老年男性中观察到血清鸢尾素水平降低,与骨质疏松症和骨折的风险增加相关。本片综述将从鸢尾素的来源以及和骨的生成和代谢,分析出鸢尾素与骨代谢之间的相关性。

Irisin is a myokine secreted by skeletal muscles and plays a major role in bone metabolism. A substantial body of experimental data suggests that irisin can promote bone formation, protect bone cells from dexamethasone-induced apoptosis, prevent the loss of bone and muscle mass, and accelerate fracture healing. Lower serum levels of irisin have been observed in postmenopausal women and elderly men, associated with an increased risk of osteoporosis and fractures. This review will cover the origins of irisin as well as its role in bone formation and metabolism, analyzing the relationship between irisin and bone metabolism.