摘要
本文以4-氯乙酰乙酸乙酯为起始原料,经还原、环合、水解三步反应合成了4-羟基-2-氧代-1-吡咯烷乙酸;该方法具有原料易得,制备过程简单、产率及产物纯度高等优点。
Taking ethyl 4-chloroacetoacetate as starting material, 4-Hydroxy-2-oxo-1-pyrrolidine acetic acid was synthesized via three steps of reduction, cyclization and hydrolysis. The improved process has the advantages of cheaper raw materials, easier operation, higher yield and purity.
出处
《化学工程与技术》
2017年第5期236-239,共4页
Hans Journal of Chemical Engineering and Technology
基金
贵州省高等学校创新能力提升计划(黔教合协同创新字[2013]04)
贵州省普通高等学校药物化学工程研究中心(黔教合KY字[2014]219号)。
