MgO-Al₂O₃复合氧化物催化合成1-(3-二乙氨基苯氧基)-2-丙醇

Synthesis of 1-(3 Diethylaminophenyloxy)- 2-Propanol Catalyzed by MgO-Al₂O₃ Composite Oxides

以3-羟基-N,N-二乙基苯胺与1,2-环氧丙烷为反应物,在碱性催化剂的作用下合成1-(3-二乙氨基苯氧基)-2-丙醇。作者研究了催化剂组成和制备工艺对催化合成1-(3-二乙氨基苯氧基)-2-丙醇反应的影响。结果显示,当镁铝摩尔比为0.0015,经过300℃煅烧制成的MgO-Al2O3复合氧化物表现出高效的催化性能。通过实验得到的最佳工艺条件为:反应温度为120℃,反应时间为5 h,反应物摩尔比n(3-羟基-N,N-二乙基苯胺):n(1,2-环氧丙烷) = 1:1.7,催化剂投料量为1 wt%。在此工艺条件下,1-(3-二乙氨基苯氧基)-2-丙醇的产率达到81.78%,转化率为93.06%,选择性为88.39%。

1-(3-Diethylaminophenyloxy)-2-propanol was synthesized with 3-hydroxy-N,N-diethylaniline and 1,2-propylene oxide as reactants. In the presence of alkaline catalyst, 1-(3-diethylaminopheny- loxy)-2-propanol was synthesized. The effects of catalyst composition and preparation process on the catalytic synthesis of 1-(3-diethylaminophenyloxy)-2-propanol were investigated. The results showed that the MgO-Al2O3 composite oxides calcined at 300?C exhibited efficient catalytic performance when the molar ratio of Mg:Al was 0.0015. The optimum reaction condition was as follows: reaction temperature 120?C, reaction time 5 h, molar ratio of the reactants being n(3-hydroxy-N,N-diethylaniline):n(1,2-propylene oxide) = 1:1.7, and catalyst feeding ratio 1 wt%. Under the optimum reaction condition, the yield of 1-(3-diethylaminophenyloxy)-2-propanol reached 81.78%, the conversion rate was 93.06%, and the selectivity was 88.39%.