蛹虫草中抗肿瘤活性成分及作用机制研究进展

Research Progress on Anti-Tumor Active Ingredients and Anti-Tumor Mechanism of Cordyceps militaris

蛹虫草作为宝贵的生物资源,在抗肿瘤领域具有一定的食药用价值。本文首先对蛹虫草中具有抗肿瘤作用的活性成分进行整理,例如虫草多糖类物质、核苷类物质、蛋白质类物质以及甾醇类物质等。其次,根据蛹虫草的广谱抗肿瘤作用,对其直接或间接的抗肿瘤作用机制进行分类汇总,主要包含抑制嘌呤、DNA和RNA生物合成及蛋白质翻译、诱导肿瘤细胞凋亡、调控细胞周期、抗肿瘤细胞转移和侵袭、改善免疫调节、增强耐药性细胞的敏感性等。最后,在总结前人研究的基础上,提出了未来在蛹虫草抗肿瘤作用的研究中可能值得继续深入探讨的重点,为蛹虫草抗肿瘤的研究开拓思路。

As a valuable biological resource, Cordyceps militaris has certain medicinal value in the field of an-ti-tumor. This article firstly organizes the active ingredients with anti-tumor effects in Cordyceps militaris, such as cordyceps polysaccharides, nucleosides, proteinaceous substances and sterols. Secondly, according to the broad-spectrum anti-tumor effect of Cordyceps militaris, its direct or indirect anti-tumor mechanism is classified and summarized, including inhibition of sputum, DNA and RNA biosynthesis and protein translation, induction of tumor cell apoptosis, regulation of cell cycle, inhibition of tumor cell metastasis and invasion, improvement of immune regulation, en-hancement of sensitivity of drug-resistant cells, and the like. Finally, on the basis of summarizing the previous studies, the paper puts forward the focus of future research on the anti-tumor effect of Cordyceps militaris, and explores the research on anti-tumor of Cordyceps militaris.