桑叶多糖的分离纯化及其体外降血糖降血脂活性

Isolation of Mulberry Leaf Polysaccharide and Its Hypoglycemic and Lipid-Lowering Activity

桑叶多糖是桑叶中重要的功效成分,本研究采用水提法获得桑叶多糖粗提物,savage法脱蛋白,过氧化氢脱色后,获得桑叶多糖(MLP)。体外实验结果显示MLP可以显著抑制α-葡萄糖苷酶、淀粉酶、脂肪酶活性,并对胆酸盐具有较强的结合能力。研究结果表明,MLP具有较强的降血糖和降血脂活性,有望为相关疾病的预防和治疗提供一定的辅助作用。

Mulberry leaf polysaccharide is an important functional component in mulberry leaf. In this study, a crude extract of mulberry leaf polysaccharide was obtained by water extraction, protein was removed by savage method, and mulberry leaf polysaccharide (MLP) was obtained after decolori-zation by hydrogen peroxide treatment. The results of in vitro experiments show that MLP can significantly inhibit α-glucosidase, amylase, and lipase activities, and has strong binding ability to cholate. The research results show that MLP has strong hypoglycemic and lipid-lowering activities, and is expected to provide certain auxiliary effects for the prevention and treatment of related diseases.