抗菌肽在维生素D免疫调节功能中的作用

The Role of Cathelicidin in the Immune Regulation of Vitamin D

维生素D具有免疫调节功能,维生素D两次羟化形成的活性维生素D可以通过巨噬细胞和单核细胞角质形成细胞促进抗菌肽的产生和增加其抗菌活性,能抵抗病毒、细菌和真菌的侵害,可能有助于预防相关病原体感染的疾病。为了证实维生素D确实能够预防这些相关病原体感染的疾病,临床医师和营养学家应该进一步做好较大规模的随机双盲、安慰剂对照研究。

Vitamin D has the function of immunoregulation. The active vitamin D formed by twice hydroxylation of vitamin D can promote the production of cathelicidin and increase its antibacterial activity through macrophages and monocyte keratinocytes. It can resist the invasion of virus, bacteria and fungi, and may be helpful to prevent the diseases infected by related pathogens. In order to confirm that vitamin D can prevent these diseases related to pathogen infection, clinicians and nutritionists should further do a large-scale randomized double-blind, placebo-controlled study.