褐藻寡糖与肠道菌群在肥胖中的研究进展

Research Progress on Alginate Oligosaccharide and Gut Microbiota in Obesity

近年来,肥胖已成为严重的全球性公共卫生问题。肠道菌群被认为是调节宿主健康的主要因素,更被认为是参与维持能量稳态和预防治疗肥胖的关键因素。在这里,我们将报告肥胖的流行现状和影响因素、肠道菌群的组成和疾病的联系、肠道菌群代谢产物与肥胖的联系以及益生元褐藻寡糖与肥胖的联系。益生元能够被肠道菌群所利用,增加有益菌减少有害菌改善肥胖及其相关代谢紊乱。但尚未有研究表明益生元褐藻寡糖是否能够调控色氨酸代谢通路改善肥胖相关代谢综合征,这为其提供了研究思路。我们希望这能为褐藻寡糖开发利用提供理论基础和灵感。

In recent years, obesity has become a serious global public health problem. Gut microbiota is considered to be a major factor in regulating host health, and is also considered to be a key factor involved in main-taining energy homeostasis and preventing and treating obesity. Here, we report the prevalence status and influencing factors of obesity, the composition of gut microbiota and the association of disease, the relationship between the gut microbiome-derived metabolites and obesity, and the association of prebiotics, such as alginate oligosaccharide, with obesity. Prebiotics can be utilized by gut microbiota, increasing beneficial bacteria and reducing harmful bacteria to improve obesity and related metabolic disorders. However, no studies have shown whether alginate oligosaccharide can regulate tryptophan metabolic pathway to improve obesity-related metabolic syndrome, which provides research ideas. And we hope that this review will provide theoretical basis and inspiration for the development and utilization of algin oligosaccharides.