地胆草三萜提取物对S180小鼠体内抗肿瘤作用的实验研究

Anti-Tumor Effects of Triterpene Extraction from Elephantopus scaber Linn. on S180 Tumor-Bearing Mice

我们通过建立S180荷瘤模型,探索地胆草提取物对S180实体瘤的抗肿瘤研究。通过对健康雄性小鼠接种S180肉瘤随机分成对照组、环磷酰胺组以及地胆草提取物低、中、高剂量组,给药后观察探索荷瘤鼠的抑瘤率、小鼠存活时间以及胸腺和脾脏指数。结果研究表明地胆草提取物对S180实瘤小鼠具有一定的抑瘤效果:地胆草提取物高剂量组的抑瘤率为44.12%;荷瘤鼠的生存率提高至36.27%;对S180荷瘤鼠的胸腺指数和脾脏指数有一定的提高,在一定程度上能有效提高S180荷瘤鼠的免疫能力。

We explored the inhibiting effects of triterpene extraction from Elephantopus scaber Linn. by establishing S180 tumor-bearing mice model. Forty mice were randomly assigned into five groups which were the control group, cyclophosphamide group, low dose Elephantopus scaber Linn. group, middle dose Elephantopus scaber Linn. group, and high dose Elephantopus scaber Linn. group. The inhibitory rate and survival rate of S180 tumor bearing mice were observed as well as the thymus and spleen index after administration. The research results showed that the high dose triterpene extraction from Elephantopus scaber Linn. could prolonged the survival time of S180 tumor bearing mice which increased up to 36.27% and the inhibition rate was up to 44.12%. And the results of the thymus and spleen index of the experimental group showed that the triterpene extraction from Elephantopus scaber Linn. could inhibit the growth of the S180 solid tumor.