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阿昔洛韦杂质IM5和IM6的合成研究

Synthesis of Acyclovir Impurities IM5 and IM6
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摘要 阿昔洛韦,又名无环鸟苷,是一种必不可少的抗病毒类药物,主要用于单纯疱疹病毒所致的各种感染,是治疗HSV脑炎的首选药物。本论文以阿昔洛韦的杂质IM-5和IM-6为研究对象,以乙二醇为原料,设计了一条合适的阿昔洛韦杂质IM-5和IM-6的合成工艺。 Acyclovir, also known as acyclia guanosine, is an essential antiviral drug that is mainly used for various infections caused by herpes simplex virus and is the drug of choice for the treatment of HSV encephalitis. In this paper, the impurities IM-5 and IM-6 of acyclovir were studied, and a suitable synthetic process of IM-5 and IM-6 of acyclovir was designed using ethylene glycol as raw material.
作者 张钰滢 赵洋洋 高小萱 杜寒莹 黄佳雯 周心宇 胡婧彤 周德军 赵桂琴
机构地区 承德医学院中药研究所河北省中药研究与开发重点实验室
出处 《药物化学》 2024年第1期1-8,共8页 Hans Journal of Medicinal Chemistry
关键词 阿昔洛韦 杂质IM-5 杂质IM-6 合成
分类号 S85 [农业科学—兽医学]
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  • 1Crumpacker C. The pharmacological profile of famciclovir [J].Semin Dermato1,1996 ,15 ( Suppl 1) :14.
  • 2Earnshaw DL, Bacon TH, Darlison SJ ,et al. Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2 and varicella-zoster virus[ J ]. Antimicrob Agents Chemother, 1992,36(12) : 2747.
  • 3Boyd MR,Bacon TH,Sutton D. Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-l-yl) guanine (BRL 39123) in animals [ J ]. Anti-microb Agents Chemother, 1988,32(3 ) : 358.
  • 4Sutton D, Kern ER. Activity of famciclovir and petciclovir in HSV infected animals [ J ]. Antiviral Chemistry Chemother,1993,4(1):37.
  • 5Boyd MR, Bacon TH , Sutton D, et al. Antiherpesvinm activity of 9-( 4-hydroxy-3-hydroxymethylbut-l-yl ) guanine ( BRL39123 )in cell culture[J ]. Antimicrob Agents Chemother, 1987,31 (8) :1238.
  • 6Palmer J, Vogt PE, Kern ER. Treatrment of genital herpes sireflex virus infections of mice and guinea pigs with famciclovir,an oral prodrug of penciclovir [J ]. Antiviral Res, 1992, 17 ( Suppl1):113..
  • 7Schacker T, Hu HL, Koelle DM, et al. Famciclovir for the suppression of symptomatic and asymptomatic herpes simplex virus reactivation in HIV-infected persons, a double-blind, placebo-controlled trial [J ]. Ann Intern Meal, 1998,128(1) : 21.
  • 8Romanowski B,Aoki FY, Martel A Y, et al. Efficacy and safety of famciclovir for treating mucocutaneous herpes simplex infection in HIV-infected individuals, collaborative famciclovir HIV study group [J]. AIDS,2000,14(9) :1211.
  • 9Kelley, J. L., Schaeffer, Howard J. Purine acyclic nucleosides. Unambiguous synthesis of acyclovir via a furzaano [3,4-d] pyrimidine[J]. J. Heterocycl. Chem., 1986, 23(1): 271-273.
  • 10Glinka, R., Goral Z., Kotelko, B. Preparation of 9-(2-hydroxyethymethyl)guanine: US, 19920131 [P]. 1992- 04-18.

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药物化学
2024年 第1期

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