优思明联合二甲双胍治疗多囊卵巢综合征的疗效Meta分析

Meta-Analysis of the Efficacy of Yasmin Combined with Metformin in the Treatment of Polycystic Ovary Syndrome

目的:系统评价优思明联合二甲双胍治疗多囊卵巢综合征(Polycystic ovary syndrome, PCOS)的疗效和安全性。方法:检索中国知网、万方、维普、CBM、PubMed、the Cochrane Library、EMBASE数据库,检索时间为建库至2023年12月8日。共纳入31篇研究,研究对象共2792例,其中观察组1396例,对照组1396例。结果:Meta分析结果表明,观察组与对照组相比,在提高临床总体有效率(RR = 1.25, 95%CI [1.18, 1.33], P 0.05)和促卵泡生成素FSH (MD = −0.40, 95%CI [−0.92, 0.13], P > 0.05)的没有统计学意义上的差异。结论:联合使用优思明和二甲双胍可以改善多囊卵巢综合征患者体内的激素紊乱水平、提高的妊娠能力、缓解体脂过高。

Objective: To evaluate the efficacy and safety of Yasmin combined with metformin in the treatment of Polycystic ovary syndrome (PCOS). Methods: the databases of CNKI, Wanfang, VIP, CBM, PubMed, the Cochrane Library and EMBASE were searched from December 8, 2023. A total of 31 studies were included, with a total of 2792 subjects, including 1396 in the observation group and 1396 in the control group. Results: meta-analysis showed that compared with the control group, the clinical overall response rate (RR = 1.25, 95%CI [1.18, 1.33], P 0.05) and follicle-stimulating hormone FSH (MD = −0.40, 95%CI [−0.92, 0.13], P > 0.05). Conclusion: Combined use of Yasmin and metformin can improve hormone disturbance levels, increase pregnancy capacity, and reduce high body fat in patients with PCOS.