ACSL4在肿瘤中的研究进展

Research Progress of ACSL4 in Cancer

ACSL4是长链酰基辅酶A合成酶家族的一员,参与机体脂肪代谢,主要催化花生四烯酸和二十碳五烯酸。其在许多肿瘤中都有不同程度的表达,且通过不同途径调控着肿瘤的发生发展,生长增殖以及侵袭迁移。本文就近年来ACSL4在肿瘤中的相关研究,包括肝癌、胃癌、前列腺癌、乳腺癌、结直肠癌、卵巢癌等方面进行阐述,为临床治疗肿瘤提供新的理论依据和指导思路。

ACSL4 is a member of the long chain acyl-CoA synthetase family, which is involved in body fat metabolism and mainly catalyzes arachidonic acid and eicosapentaenoic acid. It is expressed in many tumors to varying degrees, and regulates the occurrence, development, growth, proliferation, invasion and migration of tumors through different ways. In this paper, the relevant studies of ACSL4 in cancer in recent years are described in liver cancer, gastric cancer, prostate cancer, breast cancer, colorectal cancer and ovarian cancer, providing new theoretical basis and guidance for clinical treatment of tumor.