维生素C在眼部的抗氧化作用研究进展

The Research on the Antioxidant Effect of Vitamin C in the Eye

氧化应激是机体内氧自由基的产生超过其清除能力的一种代谢失衡的病理状态[1]。年龄老化、超重、紫外线照射、辐射、吸烟、药物及环境污染等内源性、外源性自由基的侵袭都可造成机体的氧化应激。氧化应激损伤也是一系列疾病的共同病理过程之一,眼科疾病也不例外[2]。在正常情况下,眼睛各个组分都存在一定种类、一定含量的抗氧化剂,与氧化应激之间形成动态平衡,保护眼部各组分的正常生理功能。因此,眼部抗氧化剂活性的研究对眼科疾病的诊断及防治非常重要。本文就抗氧化剂维生素C在眼部的抗氧化作用机制进行了较为全面的综述。

Oxidative stress is a pathological state of metabolic imbalance that the generation of oxygen free radicals in body exceeds the elimination. Endogenous and exogenous factors including aging, overweight, ultraviolet light, radia- tion, smoking, drugs and environment pollution can cause the oxidative stress. Oxidative stress is one of a series of common pathological processes in a range of diseases, and it has no exception in ophthalmic disease. Under normal circumstances, a dynamic balance between oxidants and antioxidants in eye exists. Therefore, the research on antioxidant activity of the eye has significant value in diagnosis and prevention of ophthalmic disease. In this paper, we carried out a comprehensive overview about the antioxidant mechanism of antioxidant vitamin C in eye.