啮齿动物高眼压模型的研究进展

Research Progress of Rodent Ocular Hypertension Model

青光眼是一种神经退行性疾病,其特征为视网膜神经节细胞(Retinal Ganglion Cell, RGC)逐渐丧失,其主要危险因素为眼内压升高(Intra-Ocular Pressure, IOP)。目前,青光眼的发生发展过程尚不十分明确,青光眼的啮齿动物模型极大地改善了我们对青光眼病理生理的理解,并成为研究神经保护剂的有用工具。本文通过对国内外诱发啮齿动物高眼压所致青光眼的模型进行总结,分析、讨论了每种模型的优越性和局限性。

Glaucoma is a neurodegenerative disease characterized by the gradual loss of retinal ganglion cells (RGC), and its main risk factor is increased intraocular pressure (Intra-Ocular Pressure, IOP). At present, the occurrence and development process of glaucoma is not very clear. The rodent model of glaucoma has greatly improved our understanding of the pathophysiology of glaucoma and has become a useful tool for studying neuroprotective agents. This article summarizes the models of glaucoma caused by high intraocular pressure in rodents at home and abroad, analyzes and discusses the advantages and limitations of each model.