边缘性角膜溃疡的研究现状

Research Status of Marginal CornealUlcer

边缘性角膜溃疡(Peripheral Ulcerative Keratitis, PUK)是一种主要发生在角膜边缘的新月型的炎症性疾病,主要表现为角膜上皮缺损和角膜基质破坏;主要与自身免疫及边缘角膜的特殊解剖部位及生理学特征及环境等因素有关。PUK可能是局部或全身的感染及非感染性病因所致。本综述总结了与非感染性PUK相关的临床特征、发病机制和疾病,以及近期开发的治疗方案。

Peripheral ulcerative keratitis (PUK) is a crescent-shaped inflammatory disease that mainly occurs in the corneal margin, and its manifestations are corneal epithelial defect and corneal stromal destruction. It is mainly related to autoimmunity, special anatomical and physiological features of marginal cornea and environmental factors. PUK may be due to local or systemic infection and non-infectious etiology. This review summarizes the clinical features, pathogenesis, and disease associated with non-infectious PUK, as well as recently developed treatment options.