洛尔类药物预防LASIK术后屈光回退的Meta分析

Meta-Analysis of Lorazepam for the Prevention of Refractive Error Regression after LASIK

目的:评估噻吗洛尔、卡替洛尔降眼压预防LASIK术后屈光回退的有效性。方法:运用Reviews Manager 5.3对术后裸眼视力、屈光度、等效球镜度、眼压、角膜曲率、角膜厚度、diff值等数据进行meta分析。结果:纳入13篇文献,共1532例2443眼。Meta分析结果显示:与对照组相比,试验组裸眼视力更佳(MD = −0.05, 95% CI (−0.06, −0.04)),屈光度更小(MD = 0.56, 95% CI (0.52, 0.60)),等效球镜度数更低(MD = 0.24, 95% CI (0.18, 0.29)),眼压较低(MD = −1.09, 95% CI: (−1.72, −0.45)),角膜曲率更低(MD = −0.22, 95% CI (−0.36, −0.09)),角膜厚度无明显差异(MD = −1.52, 95% CI (−5.78, 2.74)),diff值更小(MD = −10.47, 95% CI (−11.32, −9.62))。结论:洛尔类降眼压药物对预防LASIK术后屈光回退确有疗效。

OBJECTIVE: To evaluate the effectiveness of timolol and carteolol in lowering intraocular pressure to prevent refractive regression after LASIK. METHODS: Meta-analysis of the data on postoperative naked-eye visual acuity, refraction, equivalent spherical lens degree, intraocular pressure, corneal curvature, corneal thickness, and diff value was performed using Reviews Manager 5.3. RESULTS: Thirteen papers with 1532 cases and 2443 eyes were included. Meta-analysis showed that com-pared with the control group, the test group had better naked-eye visual acuity (MD = −0.05, 95% CI (−0.06, −0.04)), smaller refractive error (MD = 0.56, 95% CI (0.52, 0.60)), and lower equivalent spherical lens diopters (MD = 0.24, and 95% CI (0.18, 0.29)), lower IOP (MD = −1.09, 95% CI: (−1.72, −0.45)), lower corneal curvature (MD = −0.22, 95% CI (−0.36, −0.09)), and no significant difference in corneal thickness (MD = −1.52, 95% CI (−5.78, 2.74)), the diff value was smaller (MD = −10.47, 95% CI (−11.32, −9.62)). CONCLUSION: Loroidal IOP-lowering drugs are indeed efficacious in preventing refractive regression after LASIK.