Merkel细胞癌1例并文献回顾

A Case of Merkel Cell Carcinoma and the Review of Literature

Merkel细胞癌(MCC)是一种罕见的原发于皮肤的恶性神经内分泌肿瘤,具有高度侵袭性。其发病原因主要与紫外线直接照射以及Merkel细胞多瘤病毒感染相关。以质硬、无痛以及迅速增大的紫红色圆顶状肿瘤结节为其主要临床表现。目前MCC的诊断主要依靠临床表现、免疫组化、病理组织学及电镜检查。其主要治疗方案为:手术加放化疗。MCC侵袭性强,具有高复发率及死亡率,易误诊及漏诊。

Merkel cell carcinoma (MCC) is a rare neuroendocrine, cutaneous malignancy that is highly aggressive. MCC tumourigenesis is linked to the presence of clonally integrated Merkel cell polyomavirus (MCPyV) and mutagenesis from ultraviolet (UV) light exposure. MCC presents as a firm, painless, rapidly enlarging, red-violet cutaneous tumour nodule that is typically dome-shaped. The diagnosis of MCC mainly relies on clinical manifestations, immunohistochemistry, histo-pathology and electron microscopy. The treatment of MCC is based on surgery plus chemotherapy and radiotherapy. MCC is an aggressive malignancy with frequent recurrences and a high mortality rate. MCC is easily missed and misdiagnosed.