精子运动行为机理的CFD研究进展

Research Progress of CFD on the Mechanism of Sperm Motility

精子的使命是寻找卵子将遗传信息传给下一代,其运动规律一直以来都是生殖科学的重点研究对象。由于实验方法的局限性,计算流体力学逐渐在精子运动特性模拟研究方面发挥重要作用。目前已有研究采用有限元、边界元等流体建模方法结合阻力理论、浸入边界等流固耦合方法研究精子的鞭毛运动、导航特性、相互作用等机理。本文对精子运动机理研究现状以及相关CFD模拟研究进行了总结论述,介绍了研究中各类方法及相关应用,并在此基础上对未来精子CFD模拟研究的发展进行了展望。

The mission of sperm is to find the egg and pass on the genetic information to the next generation. Its movement rules have always been the focus of reproductive science. Due to the limitations of experimental methods, computational fluid dynamics (CFD) has gradually played an important role in the simulation of sperm motility. At present, fluid modeling methods such as finite element method, boundary element method and so on, combined with fluid structure coupling method which includes resistive force theory and immersion boundary etc., have been used to study the mechanism of sperm flagellum movement, navigation characteristics and interaction. The status of sperm motility mechanism research and relevant CFD simulation research are summarized and discussed in this paper, which will introduce various methods and related applications. On this ba-sis, the future development of CFD simulation research on spermatozoon is prospected.