摘要
自闭症临床表现为行为障碍,存在着免疫异常、氧化应激改变甚至基因异常。自闭症患儿普遍存在着维生素D缺乏。维生素D除了传统的钙磷代谢调节作用外,尚具有免疫调节、增加谷胱甘肽的合成及基因稳定等功能。我们最新的研究表明维生素D能够改善自闭症患儿的行为,提示维生素D参与了自闭症的致病过程。本文就维生素D在自闭症中的可能作用的研究进展作一综述。
Autism is characterized by abnormal immunology, altered oxidative stress and even genetic ab-normality in addition to behavioral problems. Vitamin D deficiency is ubiquity in children with autism. Vitamin D plays a role in regulating immune, up-regulating glutathione, and controlling genome in addition to traditional action on calcium and phosphate regulation. We recently reported that vitamin D supplementation could improve the behavioral manifestations in autistic child, which illustrated that vitamin D was involved in the pathogenesis of autism. Herein we summarize the research progress of the role of vitamin D in autism.
作者
贾飞勇
单玲
冯俊燕
王冰
李洪华
杜琳
Feiyong Jia;Ling Shan;Junyan Feng;Bing Wang;Honghua Li;Lin Du(Department of Pediatric Neurology and Rehabilitation, First Hospital of Jilin University, Changchun)
出处
《国际神经精神科学杂志》
2014年第4期21-27,共7页
International Journal of Psychiatry and Neurology
关键词
自闭症
维生素D
免疫调节
氧化应激
基因稳定
Autism
Vitamin D
Immunologic Regulation
Oxidative Stress
Genomic Stability