嘌呤2受体介导的初级感觉神经节神经元胞体与卫星胶质细胞间信息交流的研究进展

Puriner 2 Receptor Mediating the Communication between Neurons Cell Body and Satellite Glial Cells in Primary Sensory Ganglion

初级感觉神经节神经元胞体和围绕其周围的卫星胶质细胞的结构和功能研究表明,卫星胶质细胞参与了感觉信号从神经末梢传入脊髓的过程。卫星胶质细胞与其围绕的神经元胞体之间通过多种方式相互交流,这种信息交流在损伤情况下可发生改变并引发异常疼痛。本文就初级感觉神经节中嘌呤2(P2)受体介导的神经元胞体与卫星胶质细胞之间交流的可能机制及组织或神经损伤时将如何影响这种交流的研究进展进行综述。

The reaserch of structure and function on neuron cell body and satellite glial cells in primary sensory ganglion shows that satellite glial cells involved in the process of sensory signals conducted from nerve endings to the spinal cord. Satellite glial cells communicate with neurons in different ways, this kind of information communication under the condition of damage can change and cause abnormal pain. In this paper, we summarized the research progress of the communication mediated by purines 2(P2) receptor in the primary sensory ganglion, including the possible mechanisms of communication and change of communication when tissue or nerve is injured.