核素显像在快速眼球运动期睡眠行为障碍中的研究进展

Research Progress of Radionuclide Imaging in Rapid-Eye Movement Sleep Behavior Disorder (RBD)

快速眼球运动(REM rapid-eye-movement)期睡眠行为障碍(REM sleep behavior disorder, RBD)是一种由于REM睡眠期的正常肌肉失弛缓,而呈现出梦境相关的复杂运动的疾病,可表现为喊叫、怒骂、踢打,以及暴力相关的梦境。有病例队列研究随访发现,特发性RBD经时间进展14年后发展为神经变性病概率高达92%,即特发性RBD可作为神经变性病前驱症状。近年来,RBD与神经变性病之间的联系被大量的研究,关于RBD转化为相关神经变性病的特征性功能相关改变的影像标志研究也在进行中。本文从RBD的特点,RBD及神经变性病相关联系入手,回顾核素显像在RBD与神经变性病相关性研究过程中的表现及进展,从而找出有意义的核素显像手段从而帮助临床诊断治疗。

Rapid-eye-movement sleep behaviordisorder (RBD) is a REM sleep parasomnia clinically characterized by muscleatonia, unpleasant dreams and vigorous behaviors (e.g. shouting punching orjumping out of bed) while sleeping. There was even a case cohort study showingthat the patients who suffer idiopathic RBD would even have a risk of up to 92%to diagnose neurodegenerative diseases within 14 years, that is, IRBD could bea preclinical marker of neurodegenerative disease. In recent years, theresearch on imaging signs of the transformation of IRBD into related neurodegenerativediseases are on study. This article focuses on the study of PET and SPECT onRBD and neurodegenerative diseases to assist the early diagnosis andintervention of clinicians of related neurodegenerative diseases.