限时饮食可能是改善精神分裂症患者代谢的新兴干预措施

Time-Restricted Feeding May Be a New Intervention to Improve Metabolism of Schizophrenia Patients

精神分裂症患者常存在显著代谢紊乱,这不仅严重影响患者的生活质量和治疗依从性,还增加了患者过早死亡的风险。生活方式干预往往是改善代谢紊乱的一线疗法,限时饮食则是一种基于昼夜节律的新兴饮食干预措施。动物研究和人类研究均显示限时饮食具有有益的代谢作用,不仅可以减轻体重,还有益于心脏代谢健康。精神分裂症和抗精神病药物引起代谢紊乱的机制和限时饮食产生有益代谢作用的机制之间存在较多的关联,所以限时饮食可能可以帮助精神分裂症患者改善其代谢问题。因此,本文主要对精神分裂症患者的代谢问题以及限时饮食的应用效果和作用机制进行综述,希望为限时饮食未来应用于精神分裂症患者以帮助他们改善代谢提供参考。

Schizophrenia patients often have significant metabolic disorders, which not only seriously affect their quality of life and treatment compliance, but also increase the risk of premature death. Life-style intervention is often the first-line treatment to improve metabolic disorders, while time-restricted feeding is a new dietary intervention based on circadian rhythm. Animal studies and human studies have shown that time-restricted feeding has beneficial metabolic effects, which can not only reduce weight, but also benefit the cardiometabolic health. There are many correla-tions between the mechanism of metabolic disorder caused by schizophrenia and antipsychotic drugs and the mechanism of beneficial metabolic effect caused by time-restricted feeding. There-fore, time-restricted feeding may help schizophrenia patients improve their metabolic problems. Therefore, this paper mainly reviews the metabolic problems of schizophrenic patients and the ap-plication effect and mechanism of time-restricted feeding, hoping to provide reference for the future application of time-restricted feeding to schizophrenic patients to help them improve metabolic problems.