海马神经发生在精神分裂症中的研究进展

Research Progress on Hippocampal Neurogenesis in Schizophrenia

海马神经发生是海马齿状回颗粒下区形成新的神经元的过程,受到各种生理或病理因素的调控。精神分裂症是一种重性精神疾病,临床上主要表现为阳性症状、阴性症状和紊乱综合征,并伴随海马神经发生异常,提示精神分裂症相关风险因子作为病理刺激影响海马神经发生。反之,调控海马神经发生对精神分裂症的早期干预和治疗也有一定的意义。该文就精神分裂症相关因子对海马神经发生的影响及调控海马神经发生在精神分裂症中的作用进行综述。

Hippocampal neurogenesis is the process of forming new neurons in the subgranular area of hippocampal dentate gyrus, which is regulated by various physiological or pathological factors. Schizophrenia is a serious neuropsychiatric disease characterized by the presence of positive symptoms, negative symptoms and disorganisation syndromes. Importantly, it is accompanied by abnormal hippocampal neurogenesis, suggesting that schizophrenia related risk factors may affect hippocampal neurogenesis. Additionally, the regulation of hippocampal neurogenesis is critical for the early intervention and treatment of schizophrenia. Therefore, here the article will review the recent progress on the effects of schizophrenia related factors on hippocampal neurogenesis and the roles of regulating hippocampal neurogenesis in schizophrenia.