摘要
目的:探讨原发性干燥综合征(pSS)患者血清中可溶性补体受体2(sCR2)的变化及意义。方法:采用ELISA法检测20例原发性干燥综合征患者和20例健康体检者血清中可溶性补体受体2的浓度,并用SPSS统计软件进行相关统计学分析。结果:pSS患者sCR2水平均明显低于健康体检者(P均<0.01),sCR2与年龄和性别无关,特别是PSS患者中抗体阳性组血清sCR2水平低于阴性对照组,存在显著的统计学意义(P <0.05),而且pSS患者血清sCR2水平与免疫球蛋白IgG及血沉存在明显负相关。结论:pSS患者血清sCR2水平明显降低,且与免疫球蛋白IgG及血沉存在明显负相关,提示sCR2可能参与pSS的发病过程。
Aim: Changes and significance of serum soluble complement receptor 2 (sCR2) in patients with primary Sjogren’s syndrome (pSS) are discussed. Methods: ELISA was developed for the determination of sera sCR2 concentration in sera of 20 pSS patients and 20 healthy volunteers. Statistical analysis was performed by using SPSS software. Results: The level of serum sCR2 in patients with pSS was significantly lower than that in healthy control .
出处
《免疫学研究》
2014年第2期17-22,共6页
Immunology Studies
