Gadd45基因表达调控对肿瘤发生的影响

Influence of Gadd45 Gene Expression Regulation on Tumor Genesis

恶性肿瘤发生发展机制是生命科学研究的热点方向。研究发现,Gadd45蛋白是重要的致癌应激反应因子,肿瘤细胞的存活受Gadd45α、Gadd45β和Gadd45γ蛋白的调节。另外,Gadd45蛋白也参加由环境和生理损伤引起的细胞周期紊乱、DNA损伤修复、细胞凋亡过程,同时在细胞发育过程中也起重要的作用。本文综述了Gadd45基因表达调控对肿瘤发生的影响。

The hot direction of life science is to explore the development mechanism of malignant tumor. Recent studies have shown that, in tumor formation, whether in vivo or in vitro, Gadd45 protein is an important factor which calls monogenic stress response. Tumor cell survival relies on Gadd45α, Gadd45β and Gadd45γ. Gadd45 protein also participates in cell cycle stagnation, DNA repair and apoptosis, which were caused by environmental and physiological damage, meanwhile plays an important role in the development process. This paper reviews the effect of Gadd45 gene expres-sion regulation in tumor genesis.