荧光聚多巴胺纳米球的合成及肿瘤光热治疗应用研究

Synthesis of Fluorescent Polydopamine Nanospheres and Application for Photothermal Therapy of Tumor

在本文中,报道了一种利用乙二胺诱导降解聚多巴胺(PDA)的方法来制备具有荧光的聚多巴胺纳米颗粒(FPNPs)并将其用于靶向生物成像。通过乙二胺还原处理PDA得到荧光的粒子能够启发我们寻求各种生物学的方法来制备具有优异光学和生物相容性的FPNPs。此外,同时利用PDA自身的良好光热转换性质,对FPNPs进行光热效率测试实验,实现在肿瘤微环境响应下诊断与治疗的结合。实验表明,FPNPs具有良好的光热转换效率,在808 nm近红外光照射下,可以实现光热治疗,显示出其在肿瘤光热治疗领域应用的巨大潜力。

In this work, fluorescent polydopamine nanoparticles (FPNPs) are reported by using the ethylenediamine (EDA)-induced degradation of as-prepared polydopamine (PDA) approach and applied for targeted bioimaging. The reductive treatment of PDA in the presence of EDA yields fluorescent nanoparticles, inspiring us to seek various biological approaches to preparing FPNPs with excellent optical and biocompatible properties. Moreover, due to the good photothermal conversion efficiency of PDA, the photothermal efficiency test of FPNPs was carried out to realize the combination of diagnosis and treatment under the response of tumor microenvironment. The results showed that FPNPs has a good photothermal conversion efficiency under 808 nm near-infrared light, showing their great potential in the field of photothermal therapy of tumor.