神经炎症对术后认知功能障碍影响的研究进展

Research Progress on the Effect of Neuroinflammation on Postoperative Cognitive Dysfunction

术后认知功能障碍是外科手术的并发症,在老年人和已存在认知障碍的患者中很常见。近年来的研究表明手术和麻醉引起的神经炎症是POCD发展的主要因素之一。此外,大量的文献侧重于识别POCD发展的潜在危险因素,以及根据神经炎症假说确定候选治疗方法。本文总结和归纳了神经炎症在POCD中可能的作用机制以及基于此所提出的干预疗法,旨在为术后认知功能障碍的预防及治疗提供一定的临床参考,优化术中管理并改善预后。

Postoperative cognitive dysfunction is a complication of surgical procedures and is common in the elderly and patients with pre-existing cognitive impairment. In recent years, studies have shown that neuroinflammation caused by surgery and anesthesia is a major factor in the development of POCD. In addition, a large body of literature focuses on identifying potential risk factors for the development of POCD, as well as identifying candidate treatments based on the neuroinflammation hypothesis. In this paper, we summarize the possible mechanism of neuroinflammation in POCD and the proposed intervention therapy based on this, aiming to provide certain clinical reference for the prevention and treatment of POCD, optimize intraoperative management and improve prognosis.