髓源性抑制细胞在宫颈癌中的研究进展

Research Progress of Myeloid-Derived Suppressor Cells in Cervical Cancer

宫颈癌(cervical cancer, CC)是目前最常见的女性生殖系统恶性肿瘤,呈年轻化发展趋势。髓源性抑制细胞(myeloid-derived suppressor cells, MDSCs)是一类具有显著免疫抑制活性的异质细胞群。MDSCs已被证明在癌症的进展中发挥重要作用,宫颈癌中也观察到循环或肿瘤浸润性骨髓源性抑制细胞(MDSCs)数量的增加。本文介绍了MDSCs的分型及其功能,本文就MDSCs在宫颈癌中的研究进展进行综述,以期更全面揭示MDSCs的作用机制,为加强宫颈癌免疫治疗的研究及其探讨。

Cervical cancer (CC) is currently the most common malignant tumour of the female reproductive system, with a trend towards younger age. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells with significant immunosuppressive activity. MDSCs have been shown to play an important role in cancer progression, and an increase in the number of circulating or tumour-infiltrating myeloid-derived suppressor cells (MDSCs) has been observed in cervical cancer. This paper introduces the typing of MDSCs and their functions, and this paper reviews the research progress of MDSCs in cervical cancer, with the aim of revealing the mechanism of action of MDSCs more comprehensively, and for strengthening the research of immunotherapy for cervical cancer and its exploration.