性别对轻度认知功能障碍因素相关性的研究和进展

Research and Progress on the Correlation of Gender on Mild Cognitive Impairment Factors

轻度认知功能障碍(mild cognitive impairment, MCI)是指患者出现记忆力或其他认知功能减退,但未达到痴呆的诊断标准,是一种介于正常衰老与痴呆之间的认知功能障碍。MCI易转发为痴呆,且发病率随年龄的增长而增高。MCI的危险因素分为不可控性危险因素和可控性危险因素。对MCI相关因素的研究,有利于痴呆的早期干预和治疗,减轻人民、社会及国家负担,具有良好的社会价值和经济效益。本文对轻度认知功能障碍有关流行病学、载脂蛋白E4型基因、影像、危险因素及危险因素的多模态干预的最新相关研究及进展进行阐述。

Mild cognitive impairment (MCI) refers to the decline of memory or other cognitive functions in patients who do not meet the diagnostic criteria for dementia, and is a cognitive impairment between normal aging and dementia. MCI tends to be relegated to dementia, and the incidence increases with age. The risk factors for MCI are divided into uncontrollable risk factors and controllable risk factors. The study of MCI-related factors is conducive to the early intervention and treatment of dementia, reduces the burden on the people, society and the country, and has good social value and economic benefits. This article reviews the latest research and progress on epidemiology, apolipoprotein E4 gene, imaging, risk factors, and multimodal interventions for mild cognitive impairment.