应激反应和凝血功能关系的研究现状

Research Status of Stress Response and Coagulation Function

应激反应和凝血反应联系密切,甚至可以将凝血反应视为应激反应其中的一种,大量的研究已经证实机体针对应激的凝血反应可以导致血液的高凝状态,进而防止受伤部位的失血过多,因此应激诱导的高凝状态可能代表对出血的适应性反应。并且在生化上,心理压力与凝血途径之间的关系已经建立起来。由于血栓形成是心血管疾病最常见的潜在病理学,因此理解应激与该病理之间关联的机制非常有价值。本综述全面回顾在健康个体和心血管疾病患者中应激与血栓形成之间关系的细胞和分子机制。Stress response and coagulation response are closely related, and can even be regarded as a type of stress response, and a large number of studies have confirmed that the body’s coagulation response to stress can lead to a hypercoagulable state of blood, thereby preventing excessive blood loss in the injured area, so stress-induced hypercoagulability may represent an adaptive response to bleeding. And biochemically, the relationship between psychological stress and coagulation pathways has been established. Since thrombosis is the most common underlying pathology of cardiovascular disease, it is valuable to understand the mechanisms underlying the association between stress and this pathology. This review comprehensively reviews the cellular and molecular mechanisms of the relationship between stress and thrombosis in healthy individuals and people with cardiovascular disease.