摘要
以2,3,5-三甲基吡啶为起始原料,经N-氧化、硝化、亲核取代、重排水解和氯甲基化等五大步骤而制得2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成与工艺。并通过1HNMR、FT-IR、HPLC等测试手段对2-氯甲基-3,5-二甲基-4-甲氧基吡啶产品进行定性和定量分析。
2-Chloromethyl-3,5-dimethyl-4-methoxypyridine was synthesized by use of 2,3,5-trimethylpyridine as the starting material. The synthetic route contains five steps including N-oxidation, nitration, nu-cleophilic substitution, alcoholation and chloromethylation. The target product was qualitatively and quantitatively analyzed using 1H NMR, FT-IR, and HPLC testing methods.
作者
陈向莹
范芳芳
夏佳美
张千峰
Xiangying Chen;Fangfang Fan;Jiamei Xia;Qianfeng Zhang(Institute of Molecular Engineering and Applied Chemistry, Anhui University of Technology, Ma’anshan Anhui)
出处
《有机化学研究》
2016年第4期100-104,共5页
Journal of Organic Chemistry Research
基金
校企产学研合作项目(项目编号:GX20150112a)。
