路易斯酸催化的芳基C-糖苷化研究进展

Progress in Lewis Acid Catalyzed Aryl C-Glycosylation

芳基C-糖苷类化合物作为糖基转移酶和糖苷酶的抑制剂,在一系列生物过程也作为调节剂,针对各种疾病,应用芳基C-糖苷类化合物所研发的药物也得到成功的开发,由于它优异的生物与化学性质,在过去几十年中合成芳基C-糖苷类化合物,已经引起了众多生物学家与化学家的关注,成为快速发展的领域。一直以来,芳基C-糖苷化合物都存在合成困难的问题,本文基于国内外学者对芳基C-糖苷类化合物的研究,总结了由路易斯酸催化的芳基C-糖苷化的研究进展,并且进行了类别讨论,涵盖了1983年至2017年的文献。希望本文可以为相关研究工作者提供参考与帮助。

Aryl C-glycosides,as inhibitors of glycosyltransferases and glycosidases,act as regulators in a range of biological processes.The drugs based on the aryl C-glycosides for the therapy of various diseases have also been successfully developed.Due to its excellent biological and chemical properties,the synthesis of aryl C-glycosides in the past few decades has attracted the attention of many biologists and chemists and has become a rapidly growing research field.However,there are always some difficulties in the synthesis of aryl C-glycoside compounds.Based on the studies of aryl C-glycoside compounds by domestic and foreign scholars,this paper summarizes the research progress on the Lewis acid-catalyzed aryl C-glycosylation,and discusses the classification of synthetic methods.This review covers the literature from 1983 to 2017 and provides references and help for relevant researchers.