合成白藜芦醇糖苷的研究进展

Research Progress in the Synthesis of Resveratrol Glycosides

白藜芦醇糖苷是一种分布在自然界中的二苯乙烯类天然产物。白藜芦醇糖苷具有很高的药用价值,如镇咳、平喘、降血脂等多种药理作用。它的药理作用和白藜芦醇相近,其药用价值相对白藜芦醇有明显的提升。研究表明,糖苷化的白藜芦醇在药理上有较好的生物利用度和靶向性,因其独特的优势引起了众多化学与生物研究者的关注。本文收集了白藜芦醇糖苷的研究进展,包括生物酶合成法和化学合成法并进行了讨论,希望能为进一步研究开发利用白藜芦醇糖苷提供一定的参考。

Resveratrol glycoside is a stilbene natural product distributed in nature. Resveratrol glycosides have high medicinal value, such as anti-tussive, anti-asthmatic, hypolipidemic and other pharmacological effects. Its pharmacological action is similar to that of resveratrol, and its medicinal value is significantly improved compared with resveratrol. Studies have shown that glycosidic resveratrol has good bioavailability and targeting in pharmacology, which has attracted the attention of many chemical and biological researchers because of its unique advantages. This paper collects and discusses the research progress of resveratrol glycosides, including biological enzymatic synthesis and chemical synthesis, hoping to provide some reference for further research, development and utilization of resveratrol glycosides.